In mapping the hermeneutical scopes of neuroethics (Topics in Cognitive Science, 2(3), July 2010) the authors propose an “Integrated-Unified Scientific Analogy” (I-USA) model to delineate the complexities of moral dilemma we are facing critically. Based on meta-review (“neuroethics” in PubMed) and scientific analogy (Gentner, D., 2010) method, the authors conceptualize an I-USA model that optimally comprises multiple factors from the following disciplines: (1) neuroeconomics (2) neurogenetics (3) positive neuroscience (emotional activation, empathy and altruism, Tor Wagner, et al., 2002; Moritz de Greck, et al., 2011; Reuter, M., et al., 2010), (4) affective/cultural neuroscience (cultural values and differences, Wang, G., et al., 2011) (5) neurotheology (religious and spiritual, Ashbrook, J., 1989, 1992; Newberg, A. B., & Iverson, J., 2003; Lee, S. B., 1994, 1995), and (6) cognitive neuroscience (fMRI and neuroscientific, Tsukiura, T., & Cabeza, R., 2011; Cohen, M., 2001). The “I-USA” intends to optimally unify most of relevant factors for neuroethics.